Synchronous adenocarcinomas of the papilla major and minor.

CONTEXT Synchronous malignancies affecting both the major and minor papilla are rare and are usually of endocrine origin. CASE REPORT A 60-year-old female presented with a two-week history of progressive jaundice and pruritus. Evaluation revealed features of a periampullary malignancy. A Whipple pancreaticoduodenectomy was done. There was a growth in the ampulla of Vater and another in the region of the minor duodenal papilla. On histopathology, both lesions were adenocarcinomas. CONCLUSION Although rare, synchronous adenocarcinomas can occur in the major and minor papilla.